Widespread cellular distribution of aldehyde oxidase in human tissues found by immunohistochemistry staining
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[1] Hyogo College of Medicine
Hyogo College of Medicine
Japón
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- Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 16, Nº. 3, 2001, págs. 745-753
- Idioma: inglés
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Resumen
Aldehyde oxidase (EC 1.2.3.1) is a xenobiotic metabolizing enzyme that catalyzes a variety of organic aldehydes and N-heterocyclic compounds.
However, its precise pathophysiological function in humans, other than its xenobiotic metabolism, remains unknown. In order to gain a better understanding of the role of this enzyme, it is important to know its exact localization in human tissues. In this study, we investigated the distribution of aldehyde oxidase at the ce llul ar level in a variety of human tissues by immunohistochemistry. The enzyme was found to be widespread in respiratory, digestive, urogenital, and endocrine tissues, though we also observed a ceJlspecific localization in the various tissues studied. In the respiratory system, it was particularly ab und ant in epithelial cells from the trachea and bronchium, as well as alveo lar cells. In the digestive system, aldehyde oxidase was observed in surface epithelia of the small and large intestines, in add iti on to hepatic cells.
Furthermore, the proximal, distal, and COllecting tubules of the kidney were immunostained with various intensities, while g lomerulu s tissues were not. In epididymus and prostate tissues, staining was observed in the ductuli epididymidis and glandu lar epithelia.
Moreover, the adrenal gland , cortex, and notably the zona reticularis, showed strong immunostaining. This prevalent tissue distribution of aldehyde ox idase in humans suggests some additional pathophysiological functions besides xenobiotic metabolism. Accordingly, some possible roles are discussed.
