Prolonged immobilization-induced stress delays alveolar bone healing. A histometric study in rats

• Bombonato Prado, K.F. ^[1] ; Lamano Carvalho, T.L. ^[1] ; Franci, J.A.A. ^[1] ; Brentegani, L.G. ^[1]
  1. [1] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 16, Nº. 2, 2001, págs. 481-485
• Idioma: inglés
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• Resumen

  • The purpose of the present study was to investigate the effect of prolonged immobilizationinduced stress on reparative bone formation, using the rat alveolar healing as an experimental protocol. Stress was attained by immob il ization for 2 hours a day, beginning three days before extraction of the upper right incisors and continu ing until sacrifice. T he stress condition was assayed on the basis of plasma corticostero ne concentration (measured by doubleantibody radioimmunoassay), which increased by 2.5 to 4 times in rats submitted to immobil ization. The volume density of neoformed bone filling the alveolar socket was quantified by a histometric differential pointcounting method 7 to 21 days following tooth extraction.

    Stress caused a significant de lay in reparative bone increment, somewhat related to impairment of coagulum remission and/or organization.