Resumen de Inhibited differentiation of Langerhans cells in the rat epidermis upon systemic treatment with cyclosporin A

M.B. Borghi Cirri, R. Riccardi Arbi, Stefano Bacci, M. Mori, N. Pimpinelli, P. Romagnoli, F. Filipponi

• The immunosuppressant drug cyclosporin A (CsA) is known to cause reduction in number, DNA synthesis and function of Langerhans cells (LC). Since also the differentiation of LC is known to be hampered in conditions of acquired immunodeficiency not due to drugs, we investigated whether this occurs with CsA.

  Rats were injected subcutaneously with CsA (5, 10 and 50 mg.kg-1.d-1) for three weeks; the kin was analyzed by la immunohistochemistry and by electron microscopy. Epidermal immunolabeled cells were 15±3.5 (mean ± SEM) per 100 basal keratinocytes in untreated controls and 8.75±1.3, 4.75±1.0 and 1.7±1.2 upon increasing doses of CsA (p