Human lung fructose-1,6-bisphosphatase is localized in pneumocytes II

• Gizak, A. ^[1] ; Rakus, D. ^[1] ; Kolodziej, J. ^[2] ; Zabel, M. ^[3] ; Ogorzalek, A. ^[4] ; Dzugaj, A. ^[1]
  1. [1] Department of Animal Physiology, Institute of Zoology, Wroclaw University, Wroclaw, Poland
  2. [2] Lower Silesian Pulmonary Center, Department of Thoracic Surgery, Wroclaw, Poland
  3. [3] Department of Histology, Wroclaw University of Medicine, Wroclaw
  4. [4] Department of Histology, Poznan University of Medicine, Poznan, Poland

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 16, Nº. 1, 2001, págs. 53-55
• Idioma: inglés
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  • The localization of fructose-1,6-bisphosphatase (Fru-1 ,6-Pase EC 3.1.3.11) in human alveolar epithelium was determined immunohistochemically using a polyclonal antibody raised against the enzyme purified from human liver. The immunohistochemical analysis revealed that the Fru-1,6-Pase was localized in pneumocytes II and was absent in pneumocytes I. Hypothetically Fru-1,6-Pase participating in glucose-6-phosphate synthesis from noncarbohydrate precursors increases NADPH level which is used for surfactant synthesis and for glutathione redox cycle.