Tenascin in the developing and adult human intestine

• l. Belanger ^[1] ; J-F. Beaulieu ^[1]
  1. [1] Université de Sherbrooke

     Université de Sherbrooke

     CA.10.05.43027, Canadá

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 15, Nº. 2, 2000, págs. 577-585
• Idioma: inglés
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• Resumen

  • The tenascins are a family of multifunctional extracellular matrix glycoproteins subject to complex spatial and temporal pattems of expression in the course of various organogenetic processes, namely those involving epithelial-mesenchymal interactions. In the intestine, the tenascins, in particular tenascin-C, have been found to be differentially expressed in the developing and adult small intestinal and colonic mucosa as well as in neoplasm. While tenascin-C emerges as a key player likely to be involved in intestinal mucosa development, maintenance and disease, its exact role in the regulation of fundamental intestinal cell function(s) such as proliferation, migration and tissue-specific gene expression remains however to be established.