Changes in the immunoreactivity of substance P and calcitonin gene-related peptide in the laryngeal taste buds of chronically hypoxic rats

• Kusakabe, T. ^[5] ; Yoshida, T. ^[1] ; Matsuda, H. ^[1] ; Yamamoto, Y. ^[2] ; Hayashida, Y. ^[3] ; Kawakami, T. ^[4] ; Takenaka, T. ^[5]
  1. [1] Yokohama City University

     Yokohama City University

     Naka Ku, Japón

     
  2. [2] Gifu University

     Gifu University

     Japón

     
  3. [3] University of Occupational and Environmental Health Japan

     University of Occupational and Environmental Health Japan

     Kokurakita Ku, Japón

     
  4. [4] Kitasato University

     Kitasato University

     Japón

     
  5. [5] Laboratory for Anatomy and Physiology, Department of Sport and Medical Science, Kokushikan University, Tokyo

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 15, Nº. 3, 2000, págs. 683-688
• Idioma: inglés
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• Resumen

  • The distribution of substance P (SP)- and calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers in the taste buds of the epiglottis and aryepiglottic folds was compared between normoxic control and chronically isocapnic hypoxic rats (10% O2 and 3-4% CO2 for 3 months). In the normoxic laryngeal taste buds, SP- and CGRP-imrnunoreactive fibers were detected within the taste buds, where they appeared as thin processes with many varicosities. Most CGRP fibers showed coexistence with SP, but a few fibers showed the immunoreactivity of CGRP only. The density of intraand subgemmal SP and CGRP fibers penetrating into the laryngeal taste buds was significantly higher in chronically hypoxic rats than in normoxic control rats. Water intake in the hypoxic rats was significantly lower than in the normoxic rats. These results indicate that the increased density of SP- and CGRP-containing nerve fibers within the laryngeal taste buds is a predominant feature of hypoxic adaptation. The altered peptidergic innervation and reduced water intake support the hypothesis that the laryngeal taste buds are involved in water reception, and that the water reception may be under the control of peptidergic innervation.