Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin – An experimental study in rats

• Mª Ángeles Sánchez-Garcés ^[1] ; Octavi Camps-Font ^[1] ; Jaume Escoda-Francolí ^[3] ; Fernando Muñoz-Guzón ^[2] ; Jorge Toledano-Serrabona ^[1] ; Cosme Gay-Escoda ^[4]
  1. [1] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  2. [2] Universidade de Santiago de Compostela

     Universidade de Santiago de Compostela

     Santiago de Compostela, España

     
  3. [3] DDS, MS, PhD. Master in Oral Surgery and Implantology
  4. [4] MD, DDS, MS, PhD, EBOS, OMFS. Chairman and Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Barcelona. Researcher and coordinator of the IDIBELL Institute; Director of the Master of Oral Surgery and Implantology (EFHRE International University /FUCSO); Director of the Dentistry, Oral and Maxillofacial Department of Centro Médico Teknon, Barcelona, Spain

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 25, Nº. 4 (July), 2020
• Idioma: inglés
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  •  The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (β-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope.

     CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (β-TCP-Fn, β-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS).

    60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the β-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the β-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056).

     Both β-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with β-TCP-Fn are significantly better in short healing time when comparing with controls but not for β-TCP used alone in rats calvarial CSDs.