Argyrophilic nucleolar organizer region (AgNOR) counting in astrocytic gliomas: prognostic value

• Cardesa, Antonio ^[2] ; Ferreres, Joan-Carles ^[2] ; Figols, J. ^[2] ; Val-Bernal, José Fernando ^[1] ; Cruz Sánchez, F.F. ^[1]
  1. [1] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  2. [2] Department of Pathology, Marqués de Valdecilla University Hospital, Santander
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 11, Nº. 1, 1996, págs. 35-39
• Idioma: inglés
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• Resumen

  • In 87 astrocytic gliomas the number of AgNORs/nucleus was retrospectively studied and data correlated with the histological type of the tumors and survival. Al1 patients were treated by the same surgical team and with uniform criteria. Statistically significant differences (p<0.01) were found in relation with the AgNOR averages among the histological types of tumors. A statistically significant linear correlation (p<0.05) between the AgNOR values and survival of the patients was also found. Patients with mean AgNOR values higher than 2.23 and lower than 2.9 survived an average of 11.5I9.1 months vs. a sumival in average of 24.4I34.1 months with mean AgNOR values under 2.23 (p<0.05). Patients with AgNOR values higher than 2.9 survived, on average, 7.7I3.9 months. AgNOR counting in astrocytic gliomas is a reproducible, easy, quick method with prognostic value. AgNORs may be successfully applied in routine material to assess the growth potential of astrocytic gliomas.