Immunoreactivity for c-fos and c-myc protein with the monoclonal antibodies 14E10 and 6E10 in malignant mesothelioma and non-neoplastic mesothelium of the pleura

• Ramael, M. ^[1] ; Van den Bossche, J. ^[1] ; Buysse, C. ^[1] ; Deblier, I. ^[1] ; Segers, K. ^[1] ; Van Marck, E. ^[1]
  1. [1] Laboratory of Pathology, University Hospital Antwerp, Edegem, Belgium
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 10, Nº. 3, 1995, págs. 639-643
• Idioma: inglés
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• Resumen

  • We studied immunoreactivity for c-fos protein and c-myc protein in malignant mesothelioma (36 cases) and non-neoplastic pleural mesothelium (45 cases) using the murine monoclonal antibodies 14E10 and 6E10. All malignant mesotheliomas and cases with non-neoplastic mesothelium exhibited not only nuclear but also cytoplasmic immunoreactivity for c-fos and cmyc protein in the majority of mesothelial cells. There was no statistically significant difference between the various mesothelioma subtypes or between neoplastic and non-neoplastic mesothelium for c-fos protein immunoreactivity (p>0.05). There was statistically significant difference between neoplastic and nonneoplastic mesothelium for c-myc protein immunoreactivity (p<0.0 1). We conclude that immunoreactivity for c-fos and cmyc protein is present in both non-neoplastic and neoplastic mesothelium, but that a higher proportion of neoplastic mesothelial cells are immunoreactive for cmyc protein when compared with non-neoplastic mesothelium.