Demyelinating hereditary neuropathies in children: a morphometric and ultrastructural study

• Guzzetta, F. ^[3] ; Guzzetta, A. ^[3] ; Rodríguez, J. ^[1] ; Deodato, M. ^[3] ; Ferriere, G. ^[2]
  1. [1] Universidad de Valparaíso

     Universidad de Valparaíso

     Valparaíso, Chile

     
  2. [2] Université Catholique de Louvain

     Université Catholique de Louvain

     Arrondissement de Nivelles, Bélgica

     
  3. [3] Istituto di Neuropsichiatria Infantile, Universita di Messina, Policlinico Universitario, Messina, Italy

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 10, Nº. 1, 1995, págs. 91-104
• Idioma: inglés
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  • Twenty-three cases of hereditary demyelinating neuropathies are reported, 13 with different types of hereditary motor and sensory neuropathy (HMSN) and 9 with globoid cell or meta-chromatic leucodystrophies. Ultrastructural and morpho-metric studies showed some critica1 pathological features emphasizing: 1) the variability of the recessive forms of HMSN; 2) the morphological distinction between HMSN type 1 and type 111; and 3) differences between these types of HMSN and other «onion bulb» neuropathies such as those found in leucodystrophies, which account for distinct underlying mechanisms.