Effects of bombesin on the morphology and function of the rat adrenal cortex: comparison of the acute and chronic responses

• Malendowicz, L.K. ^[2] ; Nussdorfer, G.G. ^[1] ; Miskowiak, B. ^[2] ; Majchrzak, M. ^[2]
  1. [1] University of Padua

     University of Padua

     Padova, Italia

     
  2. [2] Department of Histology and Embryology, School of Medicine, Poznan, Poland
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 10, Nº. 1, 1995, págs. 11-15
• Idioma: inglés
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• Resumen

  • The acute and chronic effects of bornbesin (BM) on the structure and function of rat adrenal cortex were investigated by rnorphornetric and radioirnrnunological techniques. An intraperitoneal bolus injection of 2 yglrat BM rnarkedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusion (1 yg/rat.h-l) for 1, 2 or 4 days evoked a notable increase in the nurnber of adrenocortical cells, without inducing apparent changes in either PBC or B output by adrenal quarters. Since proliferation and expression of specialized functions are rnutually exclusive states of cells, our findings suggest that the conspicuous stirnulation of adrenocortical-cell proliferation evoked by BM infusion may be responsible for the apparent lack of effect of this treatrnent on B secretion.