Studies on the breakdown of glycogen in the lysosomes: The effects of hydrocortisone

• S.A. Kalamidas ^[1] ; O.B. Kotoulas ^[1]
  1. [1] Medical School, University cf loannina, loannina, Greece
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 15, Nº. 1, 2000, págs. 29-35
• Idioma: inglés
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• Resumen

  • The effects of hydrocortisone on newborn rat liver were studied by using biochemical assays, electron microscopy and quantitative morphometry. Hydrocortisone increased the number of Iy sosomes in the hepatocytes. Most of the Iy sosomes represented glycogen-containing autophagic vacuoles. The glucocorticoid also increased the activity of the liver glycogen-hydrolyzing acid glucosidase and the breakdown of glycogen inside Iysosomes. The activity of the liver acid man nose 6-phosphatase was decreased.

    This may be related to the stimulation of autophagic mechanisms in the newborn rat hepatocytes.