Immunohistochemical-morphometric study of the LH-adenohypophyseal cells following chronic treatment with met-enkephalin

• Rubio, M. ^[1] ; Sanchez, F. ^[1] ; Carretero, J. ^[1] ; Riesco, J. M. ^[1] ; Cabo, L. ^[1] ; Vazquez, R. ^[1]
  1. [1] Universidad de Salamanca

     Universidad de Salamanca

     Salamanca, España

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 9, Nº. 2, 1994, págs. 221-226
• Idioma: inglés
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• Resumen

  • In order to test the possible effect of chronic treatment with met-enkephalin upon the LHadenohypophyseal cells, an imrnunohistochemicalmorphometric study was carried out in rats of both sexes receiving a daily dose of 40 pg of met-enkephalin intramuscularly over 15 days. Following the administration of the opioid, a drastic decrease in the cellular, cytoplasmic and nuclear areas when compared to the normal and control animals was detected. Morphologically, the main finding in males was the appearance of irregularly-shaped pseudovacuolated cells. On the other hand, in females a decrease in the intensity of reaction was found. These results strongly suggest a decrease in the activity of the LH-adenohypophyseal cells following chronic administration of met-enkephalin.