Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive

• Carolina-Hartung Habibe ^[1] ; Rosemeire-Arai Yoshida ^[3] ; Renata Gorjão ^[2] ; Gabriela-Mancia de Gutierrez ^[4] ; Debora Heller ^[5] ; Alexander Birbrair ^[6] ; Maria-Teresa-Botti-Rodrigues Santos ^[7]
  1. [1] Centro Universitário de Volta Redonda

     Centro Universitário de Volta Redonda

     Brasil

     
  2. [2] Universidade Cruzeiro do Sul

     Universidade Cruzeiro do Sul

     Brasil

     
  3. [3] DDS, MSc student, Postgraduate Program in Dentistry, Cruzeiro do Sul University, Rua Galvão Bueno, 868 - Liberdade, São Paulo. Brazil
  4. [4] DDS, MSc, Ph.D student, Postgraduate Program in Dentistry, Cruzeiro do Sul University, Rua Galvão Bueno, 868 - Liberdade, São Paulo. Brazil
  5. [5] DDS, MSc, PhD, School of Dentistry, Cruzeiro do Sul University, Rua Galvão Bueno, 868 - Liberdade, São Paulo - SP, 01506-000, Brazil. Experimental Research Center, Albert Einstein Israeli Hospital, São Paulo, São Paulo, Brazil
  6. [6] DDS, MSc, PhD, Department of Radiology, Columbia University Medical Center, New York, New York 622 W 168th St, New York, NY 10032, EUA. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  7. [7] DDS, MSc, PhD, Associate Professor, Individuals with Special Needs, Postgraduate Program in Dentistry, Cruzeiro do Sul University São Paulo, SP, Brazil

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• Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 12, Nº. 5 (May), 2020, págs. 446-451
• Idioma: inglés
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• Resumen

  • Individuals with Down syndrome (DS) present increased susceptibility to infections and high prevalence of periodontal disease. The objective of this study is to evaluate the salivary concentrations of IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 of DS individuals and compare to cerebral palsy (CP) and normoactive patients (all with gingivitis).

    Twenty-two individuals with DS, 24 with CP and 22 normoactive participated in this cross-sectional study. Salivary flow rate, osmolality rate, Oral Hygiene Index, Gingival Index (GI) and salivary inflammatory markers IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 were evaluated. Shapiro-Wilks, Chi-square, ANOVA One-Way and Kruskal Wallis tests were applied with significance level at 5%.

    The groups were homogenous for gender, age, and IL12p70 cytokine (p>0.05). GI was significantly higher in DS compared to CP and healthy (p<0.05). CP presented reduced salivary flow and increased osmolality rate. CP showed significantly higher values for TNFα, IL10, and IL6 compared to DS and normoactive (p<0.05). DS and CP presented significantly higher values of IL-1β and IL8 compared to normoactive (p<0.05).

    Individuals with CP have higher risk to develop periodontal disease due to reduced salivary flow rate, increased salivary osmolality rate and elevated TNFα, IL-10, IL-6 compared to DS.