Indicaciones clínicas de la monitorización de azoles de uso sistémico. Hacia la optimización del tratamiento de la infección fúngica

• Autores: Emilio Cendejas Bueno, Manuel Cuenca Estrella, Alicia Gómez-López
• Localización: Revista Española de Quimioterapia, ISSN-e 0214-3429, Vol. 27, Nº. 1, 2014
• Idioma: español
• Títulos paralelos:
  • Clinical indications for therapeutic drug monitoring of antifungal agents. In the way for optimizing the treatment of fungal infection
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• Resumen

  • Therapeutic drug monitoring as a tool in the management of infectious diseases has been introduced in therapy with anti-infective agents for years. Nowadays, it has taken importance in the management of fungal diseases due to the appearance of new antifungal drugs such as new-generation azoles. These azoles have pharmacokinetic characteristics that hinder a proper use to ensure efficacy and minimize toxicity. Monitoring of serum concentrations may help in the better use of these anti-infective agents, as well as in a better management of drug interactions, infectious disease and adverse effects. It has resulted in saving costs of treatment and in avoiding inadequate dosages. This review will attempt to clarify the role of the antifungal agents Therapeutic Drug Monitoring, highlighting the role of azole compounds