PurposeNeoadjuvant chemotherapy (NACT) is employed in patients with breast cancer (BC) with the aim of reducing tumor burden and improving surgical outcomes. We evaluated the levels of energy metabolites pre- and post-radiotherapy (RT) in breast cancer (BC) patients who previously received NACT and investigated the alterations of these metabolites in relation to the patient achieving a pathologic complete response to NACT.Materials and methodsWe included 37 BC patients who were treated with NACT following surgery and analyzed the con-centrations of energy balance-related metabolites using targeted metabolomics before and one month after the end of RT. The control group was composed of 44 healthy women.ResultsPre-radiotherapy, patients had significant decreases in the plasma levels of 12 metabolites. RT corrected these altera-tions and the improvement was superior in patients with a pathologic complete response.ConclusionOur results highlight the importance of metabolism in the outcomes of patients with BC.
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