Laminin matrix formation and S-100 protein and/or desmin-positive cells in malignant fibrous histiocytoma (MFH)

Kosmehl, H. ^[1] ; Langbein, L. ^[2] ; Katenkamp, D. ^[1] ; Vogel, W. ^[1] ; Berndt, A. ^[1]
1. [1] Friedrich Schiller University Jena
  
  Friedrich Schiller University Jena
  
  Kreisfreie Stadt Jena, Alemania
2. [2] German Cancer Research Center
  
  German Cancer Research Center
  
  Stadtkreis Heidelberg, Alemania
Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 8, Nº. 3, 1993, págs. 425-428
Idioma: inglés
Enlaces
- Texto completo
Resumen
- 16/30 human storiform-pleomorphic malignant fibrous histiocytomas (MFH) showed a focal pericellular immunostaining for laminin. 14/16 of these laminin-positive tumours additionally revealed an atypical cellular differentiation (desmin- andlor S- 100 protein-positive cells). The significance of focal laminin positivity along with atypical, non-entity specific differentiated cells is discussed before the background of laminin as being an indicator and promoter of differentiation in MFH. The limited value of a laminin detection in MFH for solving differential diagnostic questions (MFH versus other poorly differentiated sarcomas with basement membrane formation) has been pointed out.