HLA molecule expression in cutaneous squamous cell carcinomas: an immunopathological study and clinical-immunohistopathological correlations

• García-Plata, D. ^[1] ; Mozos, E. ^[1] ; Carrasco, L. ^[1] ; Solana, R. ^[1]
  1. [1] Universidad de Córdoba

     Universidad de Córdoba

     Cordoba, España

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 8, Nº. 2, 1993, págs. 219-226
• Idioma: inglés
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• Resumen

  • A correlation between the lack of MHC class 1 gene expression on murine tumor cells and their ability to grow and metastasize has recently been established. This paper studies HLA-ABC and HLA-DR antigen expression in tumor cells and mononuclear infiltrate of 26 cutaneous squamous cell carcinomas (SCC). Our results showed a heterogeneous expression of HLA class 1 molecules in these tumors. No significant correlation between the degree of HLA class 1 molecule expression and anatomical-clinical parameters was found. Class 11 antigen expression was correlated to the histopathological type and to the degree of cell differentiation. Most mononuclear cells infiltrating the tumor were T-lymphocytes. No correlation with anatomical-clinical parameters was found.