Alveolar cells in cyclophosphamide-induced lung injury. II. Pathogenesis of experimental endogenous lipid pneumonia

• Sulkowski, S. ^[1] ; Sulkowska, M. ^[1]
  1. [1] Medical University of Białystok

     Medical University of Białystok

     Białystok, Polonia

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 14, Nº. 4, 1999, págs. 1145-1152
• Idioma: inglés
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• Resumen

  • An ultrastructural and histological study was made to analyse the structural and cellular features of the pulmonary lesions produced in Wistar rats by intraperitoneal (i.p.) administration of cyclophosphamide (two i.p. doses of 150 mg CP/l kg bw/l ml PBS). Rats exposed to cyclophosphamide (CP) d eve loped a condition whose morphological picture corresponded to endogenous lipid pneumonia and/or pulmonary alveolar prote inosis-like changes. Damage to the endothelium and neutrophil accumulation in lung vascular bed were found to be potentia l initiators of endogenous lipid pneumonia-typ e changes. The possibility of the evolution of the acute lung injury into endogenous lipid pneumonia-type changes and into alveolar prote inosislike changes was demonstrated. The results of the study supplement the existing theories of pulmonary alveolar proteinosis pathogenesis.