New insights into the function of noncoding RNA and its potential role in disease pathogenesis

• Askew, D.S. ^[1] ; Xu, F. ^[1]
  1. [1] University of Cincinnati

     University of Cincinnati

     City of Cincinnati, Estados Unidos

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 14, Nº. 1, 1999, págs. 235-241
• Idioma: inglés
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• Resumen

  • All polyadenylated RNAs expressed in mammalian tissues are assumed to be transported to the cytoplasm where they direct the synthesis of a protein product. This mainstream view of the function of polyadenylated transcripts is currently being challenged by the identification of a novel class of genes which, although they encode polyadenylated RNA, do not make a translated protein. Many of these noncoding RNAs are developmentally regulated or show highly restricted patterns of gene expression, and their function s are providing important insight into RNA-based mechanisms of gene expression, genomic imprinting, cell cycle progression , and differentiation. The purpose of this review is to discuss the current understanding of mammalian noncoding RNAs, and to highlight their potential for identifying new pathways of human disease.