Peanut lectin-binding sites and mucins in benign and malignant colorectal tissues associated with schistomatosis

• Lin, M. ^[1] ; Hanai, J. ^[2] ; Gui, L. ^[1]
  1. [1] Shanghai Medical College of Fudan University

     Shanghai Medical College of Fudan University

     China

     
  2. [2] Department of Pathology, Sakai Municipal Hospital, Sakai City, Osaka, Japan
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 13, Nº. 4, 1998, págs. 961-966
• Idioma: inglés
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• Resumen

  • An immunohistochemical and histochemical comparative study was carried out in benign and malignant colorectal tissues with and without schistosomiasis. This included a quantitative determination of peanut lectin (PNA)-binding sites and proliferating cell nuclear antigen (PCNA) expression and histochemical detection of mucin changes. 133 cases were studied , including 70 cases of colorectal carcinoma associated with schistosomiasis (CCS) and 63 cases of colorectal carcinoma without schistosomiasis (CC). Significant differences were found in the type of mucin-containing carcinomas (MC) between CCS and Cc. 65% of nontumorous mucosa adjacent to MC of the CCS group expressed PNA-binding sites, significantly higher than thos e of the MC in the CC group (31 %). The nontumorous mucosa in cases of MC of the CCS group also showed a high percentage of sialomucin-predominant secretion (69 %, vs 38% in MC of the CC group).

    Consistently, the presence of PNA-binding sites in MC tumors of the CCS group was increased, compared with that in the same subtype in the CC group (respectively 65% and 31 % of strong positivity for PNA). However, no differences in expression of PNA and mucin changes were demonstrated in the surrounding mucosa and tumorous tissues of non-mucin-containing carcinomas (NMC) between CCS and cc. The expression of PCNA was not different between CCS and CC and their subtypes. Our findings suggest a close relationship between mucin-containing colorectal carcinomas and schistosomiasis japonica.