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The lymphocyte-dendritic cell system

    1. [1] Division of Pathology, Yamagata Medical Center, Yamagata, Japan
    2. [2] Second Department of Pathology, Tokyo Women's Medical College, Shinjuku-ku, Japan
  • Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 13, Nº. 2, 1998, págs. 469-510
  • Idioma: inglés
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  • Resumen
    • Antigens provoke immune responses. The group of immunocompetent cells related directly to this response includes T and B cells, macrophages (M0) and dendritic cells (DCs). DCs acting as antigen-presenting cells have been recently recognized to be important in initiating the immune response.

      B cells and follicular dendritic cells (FDCs), the major immunocompetent cells in the B-cell dependent area, play an important role in humoral immunity, while T cells and interdigitating cells (IDCs), which are the major immunocompetent cells in the T-cell dependent (TD)-area, play an important role in cellular immunity.

      The B cell-IDC interaction in the TD-area is also essential for the B-cell response against TD-antigen.

      Consequently, the lymphocyte-DC interaction is essential in the response to antigenic stimulation and in inducing the potent effector cells. B cell-DC, T cell-DC and DC-B cell-T cell interactions are regulated in predetermined sites by complex and varied mechanisms.

      Much recent evidence demonstrates that DCs modulate lymphocyte biology in its broadest aspects, including generation, differen-tiation, proliferation, and activation.

      In this review, we outline recent studies on the generation, structure, and function of lymphatic tissues, propose the concept of the "Lymphocyte-Dendritic Cell System (LDS)", and finally describe the significance and functions of this system in health and disease.


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