hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease

• Fuzzati Armentero, M. T. ^[1] ; Duchosal, M. A. ^[1]
  1. [1] University Hospital of Lausanne

     University Hospital of Lausanne

     Lausana, Suiza

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 13, Nº. 1, 1998, págs. 155-168
• Idioma: inglés
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• Resumen

  • The Epste in -Barr virus (EBV) ex ists in most humans as a lifelong latent in fec tion established in hosl B ce lls afte r a primary viral enco unt er. In immunosuppressed il1ll iv iduals, such as post-transplant pati ents, the prese nce of EBV-infec ted B cells may lea d to I Y III P ho p r 0 I i fe r at i v e dis e a s e. I ni e c t io n 0 f h lJ ma n peripheral blood lymphocytes from EBV- positi ve donors into mi ce with seve re combined imlllunodefi c iency in d uces hum an Iymph op ro li fe rati ve disease in th e rec ipi e nt c lose ly rese mbling th at of hum an posttra nsplant pa tie nts. This xe noc himeric hU llla n-mouse mode l is in creasing ly he in g used to elu cida te th e mechanisms of EBV-spec ific lymphomage nesis and to assess novel therapeutic approaches.