Prognostic analysis of astrocytic gliomas correlating histological parameters with the proliferating cell nuclear antigen labelling index (PCNA-LI)

• Cruz-Sanchez, F. F. ^[1] ; Ferreres, J. C. ^[2] ; Figols, J. ^[2] ; Palacín, A. ^[1] ; Cardesa, A. ^[1] ; Rossi, M.L. ^[1] ; Val-Bernal, J.F. ^[2]
  1. [1] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  2. [2] Hospital Clinico Universitario de Valencia

     Hospital Clinico Universitario de Valencia

     Valencia, España

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 12, Nº. 1, 1997, págs. 43-49
• Idioma: inglés
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• Resumen

  • Eighty out of 250 cases of astrocy tic glioma collected from a practice served by a single c linical team ove r a 15-yea r pe ri o d were studi e d usin g a f ull compl eme nt of c lini ca l, fo llow up , histopatho log ica l analysis and proli fe rating ce ll nuc lear antigen (PC NA) immunostaining fo r the obte ntion of the PCNA-Iabe lling index (LI). A statisti ca l eva lu ati on a nd disc rimin ant analysis were carried out with the aim of clarify ing the importance of various parameters as predictors of tumor behav iour. Data are correlated with surviva l (with a 10- year follow up).

    A significant corre lation with surviva l was fo und whe n histo log ica l groupin g a nd the PC NA-LI we re studied with the Cox test. Most sign ificant features were histo log ica l as de tec ted usin g c lassica l tech niqu es in c ludin g histo log ica l g rad in g. The utili za ti o n of objecti ve va lues (mitosis, cellular density and necrosis) appears to be useful in grading astrocy ti c tumors. Our res ults e mph as ize th e impo rt a nce of cy to log ica l , histo log ical and PCNA-LI parameters as predi ctors of tumor behaviour.