SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma
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Brunno Santos de Freitas Silva [1] ; Lorena Rosa Silva [2] ; Kaique Leite de Lima [2] ; Amanda Cristina Ferreira dos Santos [2] ; Anna Carolina Oliveira [2] ; Ana Cláudia Dezzen-Gomide [1] ; Aline Carvalho Batista [2] ; Fernanda Paula Yamamoto-Silva [2]
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[1] Centro Universitário de Anápolis
Centro Universitário de Anápolis
Brasil
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[2] Universidade Federal de Goiás
Universidade Federal de Goiás
Brasil
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- Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 25, Nº. 2 (March), 2020
- Idioma: inglés
- Enlaces
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Resumen
The purpose of this experimental study was to compare the immunohistochemical expression of SOX2 and BCL-2 in Odontogenic Keratocyst (OKC) and Ameloblastoma (AB) specimens, and to identify a possible correlation in their expression.
Immunohistochemical analysis was performed to evaluate SOX2 and BCL-2 expression in OKC (n = 20) and AB (n = 20). The immunoexpression was analyzed by a quantitative and qualitative scoring system. The comparison between the immunoexpression of SOX 2 and BCL-2 was assessed by the Mann-Whitney U-test. Spearman’s correlation coefficient evaluated the correlation between SOX2 and BCL-2 expressions.
SOX2 and BCL-2 expression was observed in all specimens of OKC in the full thickness of the epithelium lining. SOX2 immunostaining was higher in OKC, in comparison with AB samples (P<0.05). BCL-2 immunostaining between OKC and AB was not statistically significant. There was no significant correlation between SOX2 and BCL-2 in OKC and AB specimens.
SOX2 and BCL-2 expressions in OKC may suggest their relationship with the biological behavior of this lesion, and the higher expression of SOX2 might be an upstream influence on the Hh signaling pathway.
