Imipenem/cilastatin sodium/relebactam fixed combination to treat urinary infections and complicated intra-abdominal bacterial infections.

• Thakare, R. ^[1] ; Dasgupta, A. ^[1] ; Chopra, S. ^[1]
  1. [1] Division of Microbiology, CSIR-Central Drug Research Institute, Sector 10 Janakipuram Extension Sitapur Road, Lucknow, Uttar Pradesh, 226031, India
• Localización: Medicamentos de actualidad = Drugs of today, ISSN 1699-3993, Vol. 56, Nº. 4, 2020, págs. 241-255
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Imipenem/cilastatin sodium/relebactam is a combination of imipenem/cilastatin, a U.S. Food and Drug Administration (FDA)-approved antibiotic, and beta-lactamase inhibitor relebactam which has been developed for the treatment of complicated urinary tract infection (cUTI) and complicated intra-abdominal infection (cIAI) due to drug-resistant bacterial pathogens. The combination (Recarbrio) has been designated as a qualified infectious disease product (QIDP) and obtained FDA approval in 2019 for the treatment of cUTI and cIAI caused by susceptible Gram-negative microorganisms in adult patients with limited or no alternative treatment options. The product was also approved by the European Medicines Agency (EMA) in 2020 for the treatment of infections due to aerobic Gram-negative organisms in adults with limited treat¬ment options.