Chemotherapy and Beyond: Infections in the Era of Old and New Treatments for Hematologic Malignancies

• Autores: Sarah Adkins, Fiona He
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 33, Nº. 2, 2019 (Ejemplar dedicado a: Management of Infectious Diseases in Stem Cell Transplantation and Hematologic Malignancy), págs. 287-308
• Idioma: inglés
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• Resumen

  • Treatment options for hematologic malignancies have been rapidly expanding in the past decade, resulting in better survival outcomes for many patients. Infection is an important cause of morbidity and mortality in this patient population. Cytotoxic chemotherapy has well-studied infectious risks related to the degree and duration of myelosuppression. Targeted therapies and immunotherapies have less clearly predictable infectious risk and diverse effects on immune function. This review discusses contemporary management of hematologic malignancies, followed by special discussion of novel agents, including signaling/small molecule inhibitors, monoclonal antibodies, immunomodulators, and immunotherapies, for treatment of hematologic malignancies with focus on infectious risk.