Correlation and association between independent variables and the presence of adverse reactions as a dependent variable in cancer patients

• Autores: Jyoti Kumar, Manjula Gudhoor, Shivakantayya Ganachari Madiwalayya
• Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 21, Nº. 4, 2019, págs. 200-204
• Idioma: inglés
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• Resumen

  • Background: Cancer is a rampant disease which can be cured or managed or prevented with the assistance of a health care team. Along with the assistance, there are certain cocktail of elements that play a vital role in achieving positive therapeutic outcome in cancer patients. Medication adherence (chemotherapy as well as supportive therapy), length of hospital stay, patient education, social economic status, marital status was few among the innumerable elements that can be specified. These factors are linked directly/indirectly to adverse drug reactions (ADR), but there is hardly few/no evidence to prove the extent relationship among these parameters with ADR as a dependent variable. The need of hour is to quantify the extent relationship of these factors in order to optimize the therapy according to the variation in the supporting factors affecting the medication therapeutic outcome in the cancer survivors. Purpose: To quantify the correlation and association of length of stay, medication adherence (chemotherapy and supportive therapy) and patient education with adverse drug reaction in cancer patients receiving chemotherapy. Procedure: A 6-months prospectivc-intervcntional study was conducted in Oncology department of KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka, India. Cancer patients receiving chemotherapy were screened; furthermore, 90 patients were recruited who fit to the inclusion criteria. All the variables were collected in validated data collection form. The results were interpreted using Spearman correlation coefficient and regression analysis. Main findings: Among 90 recruited patients, significant correlation was ob-served between ADR with length of hospital stay, chemotherapy and supportive adherence and patient education. Simultaneously, the regression analysis shows that with every unit increase in the four respective independent variables; ADR: The dependent variable increases significantly at p <0.05. Conclusion: This study concludes that substantial pharmacist efforts towards the pharmaceutical care in the oncology clinical practice which highlights the GIST of quantification of the association of the essential elements of patient care helps to improve the therapeutic outcome by revamping the adherence to the therapy by mitigating the level of adverse drug reactions faced by the cancer patients. © 2019 Rasgo Editorial S.A.. All rights reserved.