In the wake of the Human Genome Project, biomedical research has become ever more data-driven, to the point that some commentators confidently predict the end of hypothesis-driven, human-led research in favor of algorithmic data analytics. Despite the optimism for the possibilities of the new paradigm and the research funding behind it, the results of post-genomic biology have been disappointing. Cultural assumptions and structural arrangements have led to the difficulties, rooted in fundamental misunderstandings of the role of human judgment and tacit knowledge in discovery and interpretation in scientific research. A better research paradigm demands a better understanding of human judgment.
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