Cannabidiol as adjunctive treatment of seizures associated with Lennox–Gastaut syndrome and Dravet syndrome.

Simona Lattanzi; Eugen Trinka; Emilio Russo; Pasquale Striano; Rita Citraro; Mauro Silvestrini; Francesco Brigo

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Cannabidiol as adjunctive treatment of seizures associated with Lennox–Gastaut syndrome and Dravet syndrome.

Simona Lattanzi ^[1] ; Eugen Trinka ^[4] ; Emilio Russo ^[2] ; Pasquale Striano ^[5] ; Rita Citraro ^[2] ; Mauro Silvestrini ^[1] ; Francesco Brigo ^[3]
1. [1] Marche Polytechnic University
  
  Marche Polytechnic University
  
  Ancona, Italia
2. [2] Magna Graecia University
  
  Magna Graecia University
  
  Catanzaro, Italia
3. [3] University of Verona
  
  University of Verona
  
  Verona, Italia
4. [4] Paracelsus Medical University
5. [5] University of Genova
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Localización: Medicamentos de actualidad = Drugs of today, ISSN 1699-3993, Vol. 55, Nº. 3, 2019, págs. 177-196
Idioma: inglés
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Resumen
- Epilepsy is one of the most common chronic disorders of the brain affecting around 70 million people worldwide. Treatment is mainly symptomatic, and most patients achieve long-term seizure control. Up to one-third of the affected subjects, however, are resistant to anticonvulsant therapy. Lennox–Gastaut syndrome (LGS) and Dravet syndrome (DS) are severe, refractory epilepsy syndromes withonset in early childhood. Currently available interventions fail to control seizures in most cases, and there remains the need to identify new treatments. Cannabidiol (CBD) is the first in a new class of antiepileptic drugs. It is a major chemical of the cannabis plant, which has antiseizure properties in absence of psychoactive effects. This article provides a critical review of the pharmacology of CBD and the most recent clinical studies that evaluated its efficacy and safety as adjunctive treatment of seizures associated with LGS and DS.