Neonatal Acute Liver Failure

• Autores: Catherine Larson-Nath, Bernadette E. Vitola
• Localización: Clinics in Perinatology, ISSN 0095-5108, Vol. 47, Nº. 1, 2020 (Ejemplar dedicado a: Undiagnosed and Rare Diseases), págs. 25-39
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Neonatal acute liver failure (NALF) is a rare disease with a few known primary causes: gestational alloimmune liver disease (GALD), viral infections, metabolic diseases, and ischemic injury. Many cases still do not have a known cause. Laboratory evaluation may suggest a diagnosis. Most of the known causes have disease-specific treatments that improve outcomes. Survival is improving with better knowledge about and treatment options for GALD; however, overall mortality for NALF is still 24%. Liver transplant remains an important option for neonates with an indeterminate cause of NALF and those who do not respond to established treatments.