Hematopoietic and lymphatic cancers in patients with periodontitis: a systematic review and meta-analysis

• Yougen Wu ^[2] ; Xiaojun Shi ^[1] ; Yinghua Li ^[1] ; Ju Xia ^[2] ; Yuting Gu ^[2] ; Qingqing Qian ^[3] ; Yang Hong ^[4]
  1. [1] Fudan University

     Fudan University

     China

     
  2. [2] National Institute of Clinical Research, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China
  3. [3] National Institute of Clinical Research, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China; Department of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China
  4. [4] National Institute of Clinical Research, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China; Department of Osteology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 25, Nº. 1 (January), 2020
• Idioma: inglés
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• Resumen

  • Numerous studies have explored the correlation of periodontal disease (PD) with risk of hematopoietic and lymphatic cancers, but the findings were inconsistent. Therefore, we did a meta-analysis to ascertain the correlation of PD with risk of incident hematopoietic and lymphatic cancers.

    The authors searched relevant studies in databases (PubMed, Web of Science, and MEDLINE). The summary relative risk (RR) along with 95% confidence interval (CI) was calculated by use of random or fixed effects models.

    Six studies were included in qualitative synthesis. The pooled analysis revealed that PD was significantly associated with an increased risk of hematopoietic and lymphatic cancers (RR = 1.17; 95% CI = 1.07–1.27; P = 0). Stratified analysis showed the association of PD with hematopoietic and lymphatic cancers remained significant in the never smokers (RR = 1.28; 95% CI = 1.07–1.54; P = 0.007), and in the American population (RR = 1.17; 95% CI = 1.05–1.30; P = 0.003), respectively.

    Never smokers population and the American population with PD have a higher risk of developing hematopoietic and lymphatic cancers. PD might be considered as a risk factor for hematopoietic and lymphatic cancers.