CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

• Luan César da Silva ^[1] ; Felipe Paiva Fonseca ^[2] ; Oslei Paes de Almeida ^[1] ; Bruno Augusto Linhares de Almeida Mariz ^[1] ; Márcio Ajudarte Lopes ^[1] ; Raghu Radhakrishnan ^[3] ; Mohit Sharma ^[4] ; Luiz Paulo Kowalski ^[5] ; Pablo Agustin Vargas ^[1]
  1. [1] Department of Oral Diagnosis of Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil
  2. [2] Department of Oral Surgery and Pathology, School of Dentistry, University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  3. [3] Department of Oral Pathology and Microbiology, Manipal Academy of Higher Education, Manipal, India
  4. [4] Department of Oral Pathology, Sudha Rustagi College of Dental Sciences and Research, Faridabad, India
  5. [5] Department of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Center, São Paulo, Brazil.

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 25, Nº. 1 (January), 2020
• Idioma: inglés
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• Resumen

  • The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC).

    Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified.

    A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium.

    The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.