Chapter Four - Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis

• Autores: Andrew M. Thompson, William A. Denny
• Localización: Annual reports in medicinal chemistry, ISSN 0065-7743, Vol 52, 2019, págs. 97-130
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The increasing prevalence of drug resistant tuberculosis has created an urgent need for new antibiotics with novel modes of action. New drug targets include various enzymes in the electron transport pathway that are critical for maintaining growth and survival of the causative bacterium. Following approval of the ATP synthase inhibitor bedaquiline, a large number of compounds with activity against these enzymes have been identified, and a few drug candidates were recently developed that are close to or have already commenced clinical trials. Such progress is indeed promising, although the predominant focus on just three targets (NADH dehydrogenase-2, QcrB in the cytochrome bc1-aa3 supercomplex, and ATP synthase) may need to be reconsidered in light of recent findings. In this chapter, we briefly review the role of each enzyme and summarize the key results for each inhibitor class.