Resumen de Antimicrobial resistance and antibiotic consumption in Mexican hospitals

María Guadalupe Miranda Novales, Karen Flores, Yolanda López Vidal, Mauricio Rodríguez Álvarez, Fortino Solórzano Santos, José Luis Soto Hernández, Samuel Ponce de León Rosales, UNCAR Network

• Objective. To establish the current situation of antimicrobial resistance and antibiotic consumption in Mexican hospitals. Materials and methods. Antimicrobial susceptibility data from blood and urine isolates were collected. Defined daily dose (DDD) of antibiotic consumption/100 occupied beds (OBD) was calculated. Results. Study period: 2016 and 2017. Of 4 382 blood isolates, E. coli and K. pneumoniae were most frequently reported, with antimicrobial resistance >30% for most drugs tested, only for carbapenems and amikacin resistance were <20%. A. baumannii had antimicrobial resistance >20% to all drugs. Resistance to oxacillin in S. aureus was 20%. From 12 151 urine isolates, 90% corresponded to E. coli; resistance to ciprofloxacin, cephalosporins and trimethoprim/sulfamethoxazole was >50%, with good susceptibility to nitrofurantoin, amikacin and carbapenems. Global median antimicrobial consumption was 57.2 DDD/100 OB. Conclusions. This report shows a high antimicrobial resistance level in Gram-negative bacilli and provides an insight into the seriousness of the problem of antibiotic consumption.