Modeling diversity: Do homogeneous laboratory strains limit discovery?

• Autores: Clare M. Smith, Christopher M. Sassetti
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 26, Nº. 11, 2018, págs. 892-895
• Idioma: inglés
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• Resumen

  • The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a ‘case study’ to contrast the genetic landscape in natural populations with standard infection models, discussing new strategies to bridge this gap