HIV-1 latency is maintained by the estrogen receptor

• Autores: Alexis J. Bick, Janet P. Hapgood
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 26, Nº. 11, 2018, págs. 891-892
• Idioma: inglés
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• Resumen

  • Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combination with other latency-reversing agents.