Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience

• M. Lloret ^[1] ; L. García-Cabrera ^[1] ; A. Hernandez ^[1] ; N. Santana ^[1] ; L. López-Molina ^[1] ; P. C. Lara ^[2]
  1. [1] Hospital de Gran Canaria Dr. Negrin

     Hospital de Gran Canaria Dr. Negrin

     Gran Canaria, España

     
  2. [2] Instituto Canario de Investigación del Cáncer
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 21, Nº. 12 (December), 2019, págs. 1771-1775
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.

    Methods Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency.

    Results Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment.

    Conclusions Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.