Evolution of older patients diagnosed with early breast cancer in Spain between 1998 and 2001 included in El Alamo III project

• Mª D. Torregrosa ^[7] ; M. J. Escudero ^[8] ; I. Paredero ^[7] ; E. Carrasco ^[8] ; B. Bermejo ^[1] ; J. Gavila ^[2] ; J. García-Saenz ^[9] ; A. Santaballa ^[3] ; P. Martínez ^[4] ; A. Llombart ^[10] ; R. Andrés ^[11] ; N. Batista ^[5] ; A. Fernández ^[12] ; A. Antón ^[13] ; M. Seguí ^[14] ; S. Gonzalez ^[6] ; A. Ruiz ^[2] ; GEICAM, the Spanish Breast Cancer Group
  1. [1] Hospital Clinico Universitario de Valencia

     Hospital Clinico Universitario de Valencia

     Valencia, España

     
  2. [2] Instituto Valenciano de Oncologia

     Instituto Valenciano de Oncologia

     Valencia, España

     
  3. [3] Hospital Universitario La Fe

     Hospital Universitario La Fe

     Valencia, España

     
  4. [4] Hospital Universitario de Basurto

     Hospital Universitario de Basurto

     Bilbao, España

     
  5. [5] Hospital Universitario de Canarias

     Hospital Universitario de Canarias

     San Cristóbal de La Laguna, España

     
  6. [6] Mutua de Terrassa

     Mutua de Terrassa

     Tarrasa, España

     
  7. [7] Hospital Universitario Dr. Peset
  8. [8] Grupo GEICAM de Investigación en Cáncer de Mama, Madrid
  9. [9] Centro de Investigación Biomédica en Red de Oncología
  10. [10] Hospital Universitario de Lleida Arnau de Vilanova
  11. [11] Hospital Universitario Lozano Blesa
  12. [12] Complejo Hospitalario de Albacete
  13. [13] Hospital General Universitario Miguel Servet
  14. [14] Corporació Sanitaria Parc Taulli

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 21, Nº. 12 (December), 2019, págs. 1746-1753
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Introduction An increase in the number of cancer cases is expected in the near future. Breast cancer (BC) mortality rates increase with age even when adjusted for other variables. Here we analyzed BC disease-free survival (BCDFS) and BC specific survival (BCSS) in the El Alamo III BC registry of GEICAM Spanish Breast Cancer Group.

    Materials and methods El Alamo III is a retrospective registry of BC patients diagnosed between 1998 and 2001. Patients with stage I–III invasive BC of age groups 55–64 years (y), 70–74 years and ≥ 75 years were included. Patients and tumors characteristics, treatments and recurrences and deaths were analyzed.

    Results 4343 patients were included within the following age intervals: 2288 (55–64 years), 960 (70–74 years), and 1095 (≥ 75 years). Older patients (≥ 70 years) were diagnosed with more advanced tumors (stage III) than younger patients (21.5% versus 13.4%, p < 0.0001). Mastectomies were performed more on older patients and they received less chemotherapy than younger patients (66.6% versus 43.1%, p < 0.00001 and 30.8% versus 71.6%, p < 0.0001, respectively). With a median follow-up of 5.9 years, 17.7% patients had BCDFS events in the younger group and 19.8% in the older group (p < 0.0001). A decrease in BCSS was also observed in older patients, either when analyzing patients ≥ 70y (p < 0.0001) and when differentiating by the two older groups (p < 0.0001).

    Conclusions Our study suggests that older BC patients have worse outcomes what can be a consequence of receiving inadequate adjuvant treatments. Specific trials for these patients are warranted to allow us to treat them with the same scientific rigor than younger patients.