Resumen de Inmunocomplejos en pediatría. II. Investigación en enfermos neurológicos
Alfredo Blanco Quirós, R. Palencia, P. Solis Sánchez, J.A. Guisasola, Ernesto Sánchez Villares
Circulating immune complexes were investigated by polyethylene-glycol precipitation in the serum of 101 neurological patients from four mth to 15 yr old. The test was positive in 21 cases (20.7%) and 24 normal controls were negative. The polyethylene-glycol positive group had a lower seric C'3 than negative group (p<0.02). The highest positivity was found in meningoencephalitic infections with sequelae (6/6:100%) and in cerebral atrophy or very important mental deficiency (11/30:37%). The polyethylene-glycol test was not correlated with seric IgG levels, neither in positive nor in negative groups. All patients were receiving anticonvulsive treatment. The detection of circulating immune complexes may be the result of either brain tissue injury or of another immunological disturbance found in epilepsy. There was no relationship between seric immunocomplexes and the severity of epileptic disorders and it is not likely that they have any influence over seizures. The role played by anticonvulsant drugs remains unclear and further studies are needed.
