Zinc finger proteins and regulation of the hallmarks of cancer

Qin Ye ^[1] ; Jiayang Liu ^[2] ; Ke Xie ^[1]
1. [1] University of Electronic Science and Technology of China
  
  University of Electronic Science and Technology of China
  
  China
2. [2] State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, P.R. China
Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 34, Nº. 10, 2019, págs. 1097-1109
Idioma: inglés
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Resumen
- Zinc finger proteins (ZFPs) form one of the largest families of transcription factors in human genetics, via their conserved zinc finger motifs. ZFPs function in many biological processes including development, differentiation, metabolism and apoptosis.
  
  In addition, recent studies have demonstrated that ZFPs are closely associated with different stages of cancer development. One of the hallmarks of cancer is altered signal transduction cascades and an understanding of the changes in these pathways is essential for targeted cancer therapy. In this review, we discuss examples of ZFPs involved in development and progression of several types of cancer, which can provide new insights into cancer treatment