Type 2 Diabetes in Pregnancy

• Autores: Anil Kapur, H David McIntyre, Moshe Hod
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 48, Nº. 3, 2019 (Ejemplar dedicado a: Pregnancy and Endocrine Disorders), págs. 511-531
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Hyperglycemia is common during pregnancy, involving multisystem adaptations. Pregnancy-induced metabolic changes increase insulin resistance. Pregnancy-induced insulin resistance adds to preexisting insulin resistance. Preexisting pancreatic β-cell defect compromises the ability to enhance insulin secretion, leading to hyperglycemia. Women with type 2 DM have similar rates of major congenital malformations, stillbirth, and neonatal mortality, but an even higher risk of perinatal mortality. In utero type 2 DM exposure confers greater risk and reduces time to development of type 2 DM in offspring. Preconception care to improve metabolic control in women with type 2 diabetes is critical.