The impact of immunomodulatory factors from maternal diet during pregnancy on cow's milk allergy in offspring – A pilot study in the paediatric population of the Kuyavian-Pomeranian Voivodship

• M. Kuśmierek ^[2] ; I. Sardecka ^[1] ; E. Łoś-Rycharska ^[2] ; A. Krogulsk ^[2]
  1. [1] Medical University of Lodz

     Medical University of Lodz

     Łódź, Polonia

     
  2. [2] Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum Bydgoszcz, Nicolaus Copernicus UniversityToruń, Poland
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 6, 2019, págs. 570-578
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background The key role of dietary factors in immunotolerance promotion and allergic diseases prevention has been emphasised. The aim of the study was the analysis of the impact of immunomodulatory dietary components, consumed by pregnant women, on the development of cow's milk allergy (CMA) in their offspring.

    Materials and methods Fifty-one pairs of mothers and their CMA-offspring were included in the study group. The analysis of a daily intake of selected dietary components was conducted retrospectively with the application of a seven-day diet of a mother in the third trimester of gestation and the authors’ own questionnaire. The Diet 5.D programme was used.

    Results An average daily retinol intake by study-group mothers was significantly lower than by control-group mothers and valued 375.6μg/d vs. 543.7μg/d (p=0.040), respectively. Folates intake in the study group was 598.8μg/d vs. 361.1μg/d in the control group (p=0.001). Vitamin D in the study group was statistically lower – 3.6μg/d, comparing to the control group – 6.9μg/d (p=0.038). Average LC-PUFA intake by mothers with allergic children was 0.09g/d, while in the control group 0.18g/d (p=0.016). An analysis of the diet revealed that significantly more mothers of children from the control group (n=12; 48%) consumed fish 2–3 times per month in comparison to the study group (n=9; 17.6%) (p=0.007).

    Conclusions Vitamin D, A, LC-PUFA, retinol, riboflavin and fish consumption by pregnant mothers of CMA-children was significantly lower, whereas beta-carotene and folates consumption was significantly higher than that of mothers with non-allergic children.