Three DNA Polymorphisms Previously Identified as Markers for Handgrip Strength Are Associated With Strength in Weightlifters and Muscle Fiber Hypertrophy

• Elina E. Grishina ^[1] ; Piotr Zmijewski ; Ekaterina A. Semenova ^[2] ; Pawel Cieszczyk ^[5] ; Kinga Huminska-Lisowska ^[3] ; Monika Michalowska-Sawczyn ^[3] ; Ewelina Maculewicz ^[6] ; Blair T. Crewther ; Joanna Orysiak ; Elena S. Kostryukova ; Nickolay A. Kulemin ; Oleg V. Borisov ^[7] ; Sofya A. Khabibova ; Andrey K. Larin ; Alexander V. Pavlenko ; Ekaterina V. Lyubaeva ; Daniil V. Popov ^[8] ; Evgeny A. Lysenko ^[8] ; Tatiana F. Vepkhvadze ^[8] ; Egor M. Lednev ^[8] ; Elvira A. Bondareva ^[9] ; Robert M Erskine ^[4] ; Edward V. Generozov ; Ildus I. Ahmetov
  1. [1] Kazan State Medical University

     Kazan State Medical University

     Rusia

     
  2. [2] Kazan Federal University

     Kazan Federal University

     Rusia

     
  3. [3] Gdansk University of Physical Education and Sport

     Gdansk University of Physical Education and Sport

     Gdańsk, Polonia

     
  4. [4] Liverpool John Moores University

     Liverpool John Moores University

     Reino Unido

     
  5. [5] Academy of Physical Education in Katowice, Poland
  6. [6] Kaczkowski Military Institute of Hygiene Epidemiology, Warsaw, Poland
  7. [7] Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany
  8. [8] Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
  9. [9] Lomonosov Moscow State University, Moscow, Russia

  Mostrar afiliaciones +
• Localización: Journal of strength and conditioning research: the research journal of the NSCA, ISSN 1064-8011, Vol. 33, Nº. 10, 2019, págs. 2602-2607
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Muscle strength is a highly heritable trait. So far, 196 single nucleotide polymorphisms (SNPs) associated with handgrip strength have been identified in 3 genome-wide association studies. The aim of our study was to validate the association of 35 SNPs with strength of elite Russian weightlifters and replicate the study in Polish weightlifters. Genotyping was performed using micro-array analysis or real-time polymerase chain reaction. We found that the rs12055409 G-allele near the MLN gene (p = 0.004), the rs4626333 G-allele near the ZNF608 gene (p = 0.0338), and the rs2273555 A-allele in the GBF1 gene (p = 0.0099) were associated with greater competition results (total lifts in snatch and clean and jerk adjusted for sex and weight) in 53 elite Russian weightlifters. In the replication study of 76 sub-elite Polish weightlifters, rs4626333 GG homozygotes demonstrated greater competition results (p = 0.0155) and relative muscle mass (p = 0.046), adjusted for sex, weight, and age, compared with carriers of the A-allele. In the following studies, we tested the hypotheses that these SNPs would be associated with skeletal muscle hypertrophy and handgrip strength. We found that the number of strength-associated alleles was positively associated with fast-twitch muscle fiber cross-sectional area in the independent cohort of 20 male power athletes (p = 0.021) and with handgrip strength in 87 physically active individuals (p = 0.015). In conclusion, by replicating previous findings in 4 independent studies, we demonstrate that the rs12055409 G-, rs4626333 G-, and rs2273555 A-alleles are associated with higher levels of strength, muscle mass, and muscle fiber size.