Diverse developmental strategies of X chromosome dosage compensation in eutherian mammals

• Autores: Alexander I. Shevchenko, Elena V. Dementyeva, Irina S. .Zakharova, Suren M. Zakian
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 63, Nº. 3-5, 2019 (Ejemplar dedicado a: Early Mammalian Development), págs. 223-233
• Idioma: inglés
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• Resumen

  • In eutherian mammals, dosage compensation arose to balance X-linked gene expression between sexes and relatively to autosomal gene expression in the evolution of sex chromosomes. Dosage compensation occurs in early mammalian development and comprises X chromosome upregulation and inactivation that are tightly coordinated epigenetic processes. Despite a uniform principle of dosage compensation, mechanisms of X chromosome inactivation and upregulation demonstrate a significant variability depending on sex, developmental stage, cell type, individual, and mammalian species. The review focuses on relationships between X chromosome inactivation and upregulation in mammalian early development.