Immunological Functions and Evolutionary Emergence of Heavy-Chain Antibodies

• Autores: Cory L. Brooks, Martin A. Rossotti, Kevin A. Henry
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 39, Nº. 12, 2018, págs. 956-960
• Idioma: inglés
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• Resumen

  • Homodimeric antibodies devoid of light chains have evolved multiple times through convergent evolution, yet their specific immunological functions remain poorly understood. We survey the molecular and structural features of these antibodies, their immunological functions in host defense, and reflect on the long-standing question of the evolutionary forces driving their emergence