Assessment of vitamin D status in common variable immunodeficiency or ataxia–telangiectasia patients

J.R.S. Cruz; R.O.S. Sarni; R. Silva; I.G.A. Andrade; A.M. Fonseca; B. T. Costa-Carvalho

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Assessment of vitamin D status in common variable immunodeficiency or ataxia–telangiectasia patients

J.R.S. Cruz ^[1] ; R.O.S. Sarni ^[1] ; R. Silva ^[2] ; I.G.A. Andrade ^[1] ; F.L.A. Fonseca ^[3] ; B.T. Costa-Carvalho ^[1]
1. [1] Universidade Federal de São Paulo
  
  Universidade Federal de São Paulo
  
  Brasil
2. [2] Universidade Federal de Alfenas
  
  Universidade Federal de Alfenas
  
  Brasil
3. [3] ABC Faculty of Medicine, Santo André, SP, Brazil
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Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 5, 2019, págs. 499-505
Idioma: inglés
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Resumen
- Introduction and objectives Vitamin D plays a role in the immune system, however studies regarding this are scarce. This study aimed to evaluate the nutritional status of vitamin D in patients with Common Variable Immunodeficiency (CVID) or Ataxia–Telangiectasia (A–T) and to relate it to body composition, inflammatory and bone metabolism markers.
  
  Patients and methods This is a cross-sectional and controlled study involving 24 patients of both sexes (59.3% male), aged 8–56 years, with CVID (n=15) or A–T (n=9). The following variables were evaluated: body mass index (BMI), 25-hydroxyvitamin D (25 (OH) D), hepatic profile, parathormone, calcium, phosphorus, alkaline phosphatase, interleukin 6 and high-sensitivity C-reactive protein.
  
  Results The median age was 26.0 years. A deficiency of 25 (OH) D was found in four A–T patients (44%) and two CVID patients (13%). Nine patients with CVI (60%) and six with A–T (66.7%) were overweight and underweight, respectively. There was a negative correlation between vitamin D and fat mass in the CVID group, and vitamin D and BMI in the A–T group. Vitamin D was negatively associated with the percentage of total fat among the patients (β – 0.842, 95% CI: −1.5–0.17, p=0.015), R2=0.21, after adjusting for sex and age.
  
  Conclusion Vitamin D deficiency occurred in a quarter of the patients although there was no difference between the patient and the control group; without association with bone and inflammation biomarkers. The percentage of fat and BMI were negatively associated with the concentrations of 25 (OH) D.