Centro Hospitalar do Porto, Porto, Portugal

• Autores: Pinar Gur Cetinkaya, Bulent Enis Sekerel, Ozge Soyer, Saliha Esenboga, Umit Murat Sahinera, Ozlem Teksam
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 5, 2019, págs. 484-490
• Idioma: inglés
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• Resumen

  • Introduction and objectives Preschool-aged group is frequently affected by urticaria, and infections are the most frequently documented factors that cause acute urticaria in children. This prospective study was designed to investigate the underlying factors of acute urticaria in under five-year-old children and to describe predictive factors for progression to chronicity or recurrence after the first attack.

    Patients and methods Children younger than five years of age with acute urticaria were recruited between July 2015 and July 2016. Patients (n=83) were grouped into those below and above two years of age. In order to assess the risk factors for progression to chronicity or recurrence, logistic regression analysis was performed.

    Results Upper respiratory tract infection was the most common detectable reason for acute urticaria (49.4%). Herpes Simplex Virus type 1 was significantly isolated in the cases with the manifestation of an acute single-episode urticaria (p=0.042). Angioedema and food allergy were predominantly observed under two years old (p=0.001, p=0.006 respectively). A positive relationship was determined between the duration of urticaria and chronicity (r=0.301, p=0.006). The absence of atopic dermatitis (OR: 6.95, 95% CI: 1.35–35.67, p=0.020), negative Herpes virus serology (OR: 4.25, 95% CI: 0.83–21.56, p=0.040), and unknown etiology (OR: 3.30, 95% CI: 1.12–9.71, p=0.030) were the independent risk factors for recurrent urticaria.

    Conclusions Preschool-aged children with acute urticaria should be evaluated for infections at the time of admission. Patients with unknown etiology, negative Herpes virus serology, absence of atopic dermatitis, and long lasting urticaria should be followed up for chronicity and recurrence.