Post-translational modifications of HOX proteins, an underestimated issue

• Amandine Draime ^[1] ; Laure Bridoux ^[1] ; Yacine Graba ^[2] ; René Rezsohazy ^[1]
  1. [1] Université Catholique de Louvain

     Université Catholique de Louvain

     Arrondissement de Nivelles, Bélgica

     
  2. [2] Aix Marseille Université, CNRS, IBDM, France
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 62, Nº. Extra 11-12, 2018 (Ejemplar dedicado a: Hox genes: past, present and future of master regulator genes), págs. 733-744
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Post-translational modifications (PTMs) are important determinants which contribute to modulating the turn-over, intracellular localisation, molecular interactions and activity of most eukaryotic proteins. Such modifications and their consequences have been extensively examined for some proteins or classes of proteins. This is not the case for the HOX transcription factors which are crucial regulators of animal development. In this review, we provide a survey of the literature and data repositories pertaining to HOX-associated PTMs. This highlights that HOX proteins are also likely widely post-translationally modified, and defines HOX PTMs as an under-valued facet of their biology.