Regulatory landscape of the Hox transcriptome

• Ana Casaca ^[1] ; Gabriel M. Hauswirth ^[2] ; Heidi Bildsoe ^[2] ; Moisés Mallo ^[1] ; Edwina Mcglinn ^[2]
  1. [1] Instituto Gulbenkian de Ciência

     Instituto Gulbenkian de Ciência

     Oeiras e São Julião da Barra, Portugal

     
  2. [2] Monash University

     Monash University

     Australia

     
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 62, Nº. Extra 11-12, 2018 (Ejemplar dedicado a: Hox genes: past, present and future of master regulator genes), págs. 693-704
• Idioma: inglés
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• Resumen

  • Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.